What is it about?

To agree with protein and DNA sequence data, many models that modify the molecular clock hypothesis have been proposed. Most of those models do not predict the observed pattern of correlation between estimates of the average substitution rate and a measure of the variability of that rate called the "index of dispersion." The model proposed in this paper does make that prediction.

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Why is it important?

The proposed fractal Poisson model of molecular evolution, like other stochastic-rate Poisson processes, generalizes the molecular clock hypothesis by allowing its underlying substitution rate to change over time. However, unlike other stochastic-rate Poisson processes, the fractal Poisson model says molecular evolution takes place across all times scales.

Perspectives

This paper resulted from my PhD research supervised by Bruce West. For others, follow the "Related papers" link.

David R. Bickel
University of North Carolina at Greensboro

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This page is a summary of: Molecular evolution modeled as a fractal Poisson process in agreement with mammalian sequence comparisons, Molecular Biology and Evolution, August 1998, Oxford University Press (OUP),
DOI: 10.1093/oxfordjournals.molbev.a026012.
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