What is it about?
Organisms are able to maintain their proper state and functions in the face of frequent and unexpected environmental changes by deploying corrective actions via feedback control. Consequently, feedback control is a ubiquitous mechanism and a fundamental underpinning of life. Here we propose CoRa, a powerful and flexible framework that allows not only to systematically quantify the effect of feedback control in a system’s response to environmental changes, but also to boost our understanding of the many roles that feedback control plays in biological organization.
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Why is it important?
Despite the importance of feedback control, no systematic and generalizable approaches existed before to effectively evaluate its role in a biological system’s response. CoRa can be computed for biological systems of arbitrary complexity under a wide range of conditions, allowing a global view of the feedback performance. As such, this approach is poised to catalyze fast progress in our understanding of the many roles that feedback control plays in biological organization.
Perspectives
Personally, I am truly excited about our approach, CoRa, because it provides a highly informative, easy to interpret, and unifying framework to evaluate feedback control in the biomolecular context. I believe we have just started to figure out CoRa’s applications, and I hope to see it implemented in several different systems and questions.
Mariana Gómez-Schiavon
Universidad Nacional Autonoma de Mexico
Read the Original
This page is a summary of: CoRa—A general approach for quantifying biological feedback control, Proceedings of the National Academy of Sciences, August 2022, Proceedings of the National Academy of Sciences,
DOI: 10.1073/pnas.2206825119.
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